Journal: RSC Advances
Article Title: An injectable thermosensitive PLGA–PEG–PLGA hydrogel integrated with coordination-driven self-assembled MTX–Mn nanoparticles for enhanced melanoma therapy via mitochondrial dysfunction
doi: 10.1039/d6ra01096b
Figure Lengend Snippet: Synthesis and characterization of the MTX–Mn coordination nanoparticles. (A) Schematic illustration of the synthesis procedure of the MTX–Mn coordination nanoparticles. (B) Proposed coordination mechanism between MTX and Mn 2+ ions. (C) FTIR spectra of MTX and MTX–Mn. (D) 1 H NMR spectra of MTX and MTX–Mn. (E) Energy-dispersive X-ray spectroscopy (EDS) analysis confirming the presence of Mn in the MTX–Mn coordination nanoparticles. (F) Transmission electron microscopy (TEM) image of the MTX–Mn nanoparticles. (G) The particle size distribution of the MTX–Mn nanoparticles. (H) Zeta potential distribution of the MTX–Mn nanoparticles, indicating favorable surface charge and colloidal stability.
Article Snippet: The morphology of the MTX–Mn coordination particles was observed using transmission electron microscopy (TEM), and the surface elemental composition of MTX–Mn was analyzed by energy-dispersive X-ray spectroscopy (EDS) (EDAX Octane Pro).
Techniques: Spectroscopy, Transmission Assay, Electron Microscopy, Zeta Potential Analyzer